ABSTRACT
Comprendre et traiter les infections respiratoires aiguës (IRA) sont un enjeu majeur de santé publique, particulièrement en cette période de pandémie à SARS-CoV2. ECOVIR (Étude des co-détections virales dans les prélèvements respiratoires), est une étude prospective, multicentrique, en Normandie, sur deux saisons hivernales (2018–2019 et 2019–2020). L’objectif de ce projet était de créer une biothèque de prélèvements respiratoires à partir d’une cohorte de patients consultant leur médecin traitant pour des symptômes d’IRA, permettant d’étudier les co-détections virales. Trente-six médecins généralistes investigateurs (MGI), dans 8 maisons de santé normandes, ont participé à l’étude. Au total, 685 patients ont été inclus, présentant des symptômes d’IRA, et ont bénéficié d’un prélèvement nasopharyngé au cabinet médical par les MGI pour analyse virologique. Trente et un MGI/36 ont inclus des patients. La médiane d’inclusion était de 16 patients par MGI sur les 2 saisons (IC25–75 % [4,75 ;27]). De plus, 92 % des patients ont répondu à l’appel à j7, recueillant des données cliniques, environnementales, et sociodémographiques. Nous avons donc créé un vrai réseau, original, permettant d’assurer un lien entre la recherche et les soins primaires, peu représentés dans les protocoles de recherche mais qui sont la pierre angulaire de notre système de santé en France, comme nous le constatons actuellement avec la crise sanitaire.
ABSTRACT
COVID-19 is an infectious illness caused by a virus named SARS-CoV-2. Recent studies underlined the need for chest computed tomography (CT) in COVID-19 patients to assess lung involvement. However, CT has a series of disadvantages, such as the need to move the patient from an isolation room to a Radiology Department, the difficulty in protecting and disinfecting the machine, the high cost of the equipment. These disadvantages apply especially to pregnant women, in particular because of the exposure to a significant amount of radiation to the fetus. In order to avoid these disadvantages, a series of manuscript were published on the alternative use of Lung Ultrasound (LUS) during COVID-19 outbreak. Therefore, we carried out a review of the published studies and case reports, in order to underline the advantages, the correct technique, the typical LUS manifestations of COVID-19 and to help researchers in the diagnosis and monitoring of the disease, especially for obstetricians and gynecologists who already use ultrasound in their clinical practice.
ABSTRACT
PURPOSE: SARS-CoV-2 is a new pandemic influenza caused by a coronavirus which main route of transmission is through exhaled droplets that primarily infect the nose and the nasopharynx. The aim of this paper is to evaluate the effect of acetic acid, the active component of vinegar, as a potential disinfectant agent for upper airways. METHODS: Twenty-nine patients were enrolled and divided into two groups: group 1 (14 patients) was composed of patients treated with off-label hydroxychloroquine and lopinavir/ritonavir, whereas group 2 (15 patients) was composed of patients treated with hydroxychloroquine only, combined with the inhalation of acetic acid disinfectant at a 0.34% concentration. A questionnaire-based evaluation of symptoms was performed after 15 days in both groups. RESULTS: It appears that the number of patients treated with acetic acid (group 2) that experienced improvement in individual symptoms was double that of the other group of patients (group 1), although numbers are too small for robust statistical analysis. CONCLUSIONS: Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation.